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TR-FLEX Cyclotron

The TR-Flex is a further development of the proven TR-24 cyclotron platform. It is a truly unique particle accelerator. It combines the energy and power of a commercial 30 MeV cyclotron in the form of a typical PET cyclotron.


Since the commissioning of the first TR-Flex cyclotron at the Radiopharmaceutical Cancer Research Center at Helmholtz-Zentrum, Dresden-Rossendorf in 2017, the TR-Flex design has received several upgrades. With a variable energy range from 12 MeV to 30 MeV and a beam current up to 800 μA, the TR-Flex has become the most versatile and productive cyclotron in the world. It is also the most compact, non-superconducting, 30 MeV cyclotron ever built.

Features of the TR-FLEX

Variable and widest energy range

With extracted beam energy ranging from 12 to 30 MeV, the TR-FLEX is ideally suited for production of practically all medical radioisotopes, from Zr-89 nad Cu-64 to Ge-68 and Mo-99.

Highest beam current and highest output

When it comes to beam current and production capacity, the TR-Flex is available in several modifications starting from 300 μA all the way up to 800 μA, making it a small but very powerful machine that generates more beam current than any of the commercially available target systems can handle.

Small and cost effective

The TR-Flex magnet measures 1.7m x 1.7m x 1.1m and weighs only 24 tons. This is the lightest and most compact 30 MeV cyclotron. The efficiency of the TR-Flex translates into the smallest foot-print and low cost of the cyclotron vault housing this cyclotron.

A complete line of fully integrated solid, liquid and gas targets

ACSI can provide a wide variety of PET and SPECT targets that are compatible with the TR-FLEX beam power and energy. Fully integrated beamlines and automated transfer systems for both PET and SPECT radionuclides are available in standard and custom configurations. Up to 6 beamlines can be installed on the TR-FLEX cyclotron.

Big Solution,
Small Footprint

The TR-FLEX not only provides significant savings in the cost of capital equipment; it also allows for a much smaller footprint compared with standard 30 MeV cyclotrons. As a result, the investment required for construction of the whole facility, including real state costs are significantly lower.

Without beam lines the TR-Flex can can be installed in a 5m x 6m vault.

Have a Question?

Please view the list of frequently asked questions below. If you still can’t find an answer to your question(s), please feel free to contact us.

Frequently Asked Questions

What is the difference between TR-24 and TR-FLEX cyclotrons?

The TR-Flex cyclotron is built on the TR-24 platform, but it has an extended beam energy range, from 12 MeV to 30 MeV, compared to 15 MeV to 25 MeV for the TR-24. The high current model of the TR-Flex cyclotron can operate at a higher current, up to 1000 µA beam, offering a much wider and higher production capability compared to the TR-24 cyclotron.

What is the difference between TR-Flex and TR-30 cyclotrons?

The TR-Flex is a compact, cost-efficient accelerator, offering extremely high production output at a fraction of the cost of the larger TR-30 cyclotron installations. The TR-30 is ACSI’s oldest, but still most powerful cyclotron. The TR-30 has an energy range of 15 MeV to 33 MeV and up to 1600 µA current.

How big is the TR-Flex cyclotron?

The TR-Flex cyclotron is the smallest (not superconducting) 30 MeV cyclotron ever built. Its magnet, 1.7m (L) x 1.7m (W) x 1.1m (H), has a footprint of a “PET cyclotron” and it weighs only 24 tons.

Which radionuclides can be produced on the TR-Flex cyclotron?

A full range of PET radioisotopes (F-18, N-13, C-11), including radiometals (Cu-64, Zr-89, Ga-68), can be produced on the TR-Flex. Higher energy allows direct production of O-15 water from regular O-16 water. Over 30 Gbq of O-15 water can be produced in a 5 minutes run.

The TR-Flex is uniquely suited for the production of a variety of SPECT and generator nuclides:  Tc-99m, Mo-99, Ge-68, I-123, Tl-201, In-111, Zn-67, etc.